Competitor Analysis: Inhibitors of Negative Immune Checkpoints CTLA-4, LAG-3, TIM-3 & Others

Publication ID:

LMP1116001

Publication Date:

November 1, 2016

Pages:

Publisher:

La Merie Publishing

Countries:

Global [1]

USD 550.00

Pharma & Healthcare [2]

Biotechnology [3]

Healthcare [4]

Description:

Competitor Analysis: Inhibitors of Negative Immune Checkpoints CTLA-4, LAG-3, TIM-3 & Others

This Competitive Intelligence report about听Inhibitors of Negative Immune Checkpoints CTLA-4, LAG-3, TIM-3 & Others evaluates as of November 26, 2016 the competitive field of mainly specific, but also bispecific new molecular entities inhibiting negative immune checkpoints, including

CTLA-4 (Cytotoxic T-Lymphocyte-Associated Protein-4; CD152)
LAG-3 (Lymphocyte Activation Gene 3; CD223)
TIM-3 (T-cell Immunoglobulin domain and Mucin domain 3; HAVCR2)
VISTA (V-region Ig-containing Suppressor of T-cell Activation) Receptor
CEACAM1 (Carcino-Embryonic Antigen Cell Adhesion Molecule 1)
BTLA (B- and T-Lymphocyte Attenuator)
GARP (Glycoprotein A Repetitions Predominant)
TIGIT (T-cell Immunoreceptor with Ig and ITIM domains)
IL-10 (Interleukin-10)
B7-H3 (CD276)

Purchase of the pdf report includes a 6-month online access to the data of the report and any updates since the publication date as well as the clinical and preclinical combination studies. Credentials to access the database will be sent by e-mail and allow online work with the project data to print or export an individual report.

More than 10 antibodies inhibiting negative immune checkpoints are in clinical development as monotherapy or in combination with other checkpoint modulators or targeted cancer therapeutics. At least further five molecules are undergoing IND-enabling studies.

The report includes a compilation of currently active projects in research and development of immune checkpoint inhibitors. In addition, the report lists company-specific R&D pipelines of Immune Checkpoint Inhibitors. Competitor projects are listed in a tabular format providing information on:

Drug Codes,
Target / Mechanism of Action,
Class of Compound,
Company,
Product Category,
Indication,
R&D Stage and
additional comments with a hyperlink leading to the source of information.

About Competitor Analysis Series:
The Competitor Analysis Series delivers NO-FRILLS, but concise information about the pipeline of R&D projects for targets, diseases, technologies and companies at low prices. The information is provided in a tabular format and fully referenced.

Table Of Contents:

Competitor Analysis: Inhibitors of Negative Immune Checkpoints CTLA-4, LAG-3, TIM-3 & Others

Table of Contents

1) CTLA-4 Antagonists

Yervoy (ipilimumab) monotherapy
Yervoy (ipilimumab) combination with Opdivo (nivolumab)
Yervoy (ipilimumab) combination with other therapeutics
Tremelimumab monotherapy
Tremelimumab combination with durvalumab
Tremelimumab combination with other therapeutics
Novel Specific CTLA-4 Antagonists
Novel Bispecific CTLA-4 Antagonists

2) LAG-3 Antagonists

3) TIM-3 Antagonists

4) Inhibitors of Other Negative Immune Checkpoints

5) Corporate Immune Checkpoint Inhibitor R&D Pipelines

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This person cannot share the publication (or any information contained therein) with any other person or persons.
Unless a Enterprise License is purchased, a Single User License must be purchased for every person that wishes to use the publication within the same organization.
Customers who infringe these license terms are liable for a Global license fee.

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These users may print out a single copy of the publication.
These users can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher.
These users cannot share the publication (or any information contained therein) with any other person or persons outside the corporate location for which the publication is purchased.
Unless a Enterprise License is purchased, a Site User License must be purchased for every corporate location by an organization that wishes to use the publication within the same organization.
Customers who infringe these license terms are liable for a Global license fee.

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This license allows for use of a publication by unlimited users within the purchasing organization e.g. all employees of a single company.
Each of these people may use the publication on any computer, and may print out the report, but may not share the publication (or any information contained therein) with any other person or persons outside of the organization.
These employees of purchasing organization can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher.

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