
Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor (PTH1R) functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP). FORTEO (teriparatide) is recombinant human parathyroid hormone analog (1-34), marketed since 2002 for the treatment of osteoporosis and related indications where an increase of bone mass is desirable. With 2012 sales of over US$ 1 bln and the forthcoming patent expiry, teriparatide is an attractive target for biosimilar developments as well as for next generation improved PTH receptor agonist products.
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*If Applicable.