

A buffer solution is comprised of a weak conjugate acid-base pair, for example, a weak acid and its conjugate base, or a weak base and its conjugate acid. Small quantities of other acids or bases are neutralized when added to the solution, and as a result, the solution resists changes in pH. Solutions with stable pH are required for the processing of protein-based biologic APIs because of their sensitivity to changes in pH. The stable pH range and capacity (the amount of acid/base that can be added without a change in pH) of a buffer are determined by the conjugate acid-base pair.
Most purification steps for downstream processing of biologics require buffers to equilibrate, condition, wash, elute, or concentrate the product. They are used in product isolation and purification steps to facilitate protein capture and polishing and also in the filtration process for the removal of viruses or depyrogenation. Aqueous solutions are also required for cleaning and disinfecting downstream processing equipment, such as chromatography matrices and membrane filtration systems. The main equipment involved in downstream processing with buffers includes mixers for buffer preparation, as well as equipment for purification, including packed-bed chromatography systems, fluidized beds, ultrafiltration and diafiltration membranes, microfiltration membranes, depth filtration cartridges, and virus-removal systems.
Market Analysis and Insights: Global Bio Pharma Buffer Market
Due to the COVID-19 pandemic, the global Bio Pharma Buffer market size is estimated to be worth US$ 841.4 million in 2022 and is forecast to a readjusted size of US$ 1376.7 million by 2029 with a CAGR of 7.2% during the forecast period 2023-2029. Fully considering the economic change by this health crisis, Phosphates Type accounting for % of the Bio Pharma Buffer global market in 2022, is projected to value US$ million by 2029, growing at a revised % CAGR from 2023 to 2029. While Research Institution segment is altered to an % CAGR throughout this forecast period.
The key players are Avantor, Alfa Aesar (Thermo Fisher), Merck, Lonza, Bio-Rad, BD, GE, Healthcare, Promega Corporation, Hamilton Company, XZL BIO-TECHNOLOGY, SRL and so on. According to the revenue of these companies, we can know that the Bio Pharma Buffer industry is relative concentrated. Because the top 6 companies have more than 70% market share.
Global Bio Pharma Buffer Scope and Market Size
The global Bio Pharma Buffer market is segmented by company, region (country), type and application. Players, stakeholders, and other participants in the global Bio Pharma Buffer market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on sales, revenue and forecast by region (country), type and application for the period 2018-2029.
Segment by Type
Phosphates Type
Acetates Type
TRIS Type
Others
Segment by Application
Research Institution
Pharmaceutical Industry
Others
By Region
United States
Europe
China
Japan
Southeast Asia
India
Other Regions
By Company
Avantor
Alfa Aesar (Thermo Fisher)
Merck
Lonza
Bio-Rad
BD
GE Healthcare
Promega Corporation
Hamilton Company
XZL BIO-TECHNOLOGY
SRL
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1 Bio Pharma Buffer Market Overview
1.1 Bio Pharma Buffer Product Scope
1.2 Bio Pharma Buffer Segment by Type
1.2.1 Global Bio Pharma Buffer Sales by Type (2018 & 2022 & 2029)
1.2.2 Phosphates Type
1.2.3 Acetates Type
1.2.4 TRIS Type
1.2.5 Others
1.3 Bio Pharma Buffer Segment by Application
1.3.1 Global Bio Pharma Buffer Sales Comparison by Application (2018 & 2022 & 2029)
1.3.2 Research Institution
1.3.3 Pharmaceutical Industry
1.3.4 Others
1.4 Bio Pharma Buffer Market Estimates and Forecasts (2018-2029)
1.4.1 Global Bio Pharma Buffer Market Size in Value Growth Rate (2018-2029)
1.4.2 Global Bio Pharma Buffer Market Size in Volume Growth Rate (2018-2029)
1.4.3 Global Bio Pharma Buffer Price Trends (2018-2029)
2 Bio Pharma Buffer Estimates and Forecasts by Region
2.1 Global Bio Pharma Buffer Market Size by Region: 2018 VS 2022 VS 2029
2.2 Global Bio Pharma Buffer Retrospective Market Scenario by Region (2018-2023)
2.2.1 Global Bio Pharma Buffer Sales Market Share by Region (2018-2023)
2.2.2 Global Bio Pharma Buffer Revenue Market Share by Region (2018-2023)
2.3 Global Bio Pharma Buffer Market Estimates and Forecasts by Region (2024-2029)
2.3.1 Global Bio Pharma Buffer Sales Estimates and Forecasts by Region (2024-2029)
2.3.2 Global Bio Pharma Buffer Revenue Forecast by Region (2024-2029)
2.4 Geographic Market Analysis: Market Facts & Figures
2.4.1 United States Bio Pharma Buffer Estimates and Projections (2018-2029)
2.4.2 Europe Bio Pharma Buffer Estimates and Projections (2018-2029)
2.4.3 China Bio Pharma Buffer Estimates and Projections (2018-2029)
2.4.4 Japan Bio Pharma Buffer Estimates and Projections (2018-2029)
2.4.5 Southeast Asia Bio Pharma Buffer Estimates and Projections (2018-2029)
2.4.6 India Bio Pharma Buffer Estimates and Projections (2018-2029)
3 Global Bio Pharma Buffer Competition Landscape by Players
3.1 Global Top Bio Pharma Buffer Players by Sales (2018-2023)
3.2 Global Top Bio Pharma Buffer Players by Revenue (2018-2023)
3.3 Global Bio Pharma Buffer Market Share by Company Type (Tier 1, Tier 2 and Tier 3) & (based on the Revenue in Bio Pharma Buffer as of 2022)
3.4 Global Bio Pharma Buffer Average Price by Company (2018-2023)
3.5 Manufacturers Bio Pharma Buffer Manufacturing Sites, Area Served, Product Type
3.6 Manufacturers Mergers & Acquisitions, Expansion Plans
4 Global Bio Pharma Buffer Market Size by Type
4.1 Global Bio Pharma Buffer Historic Market Review by Type (2018-2023)
4.1.1 Global Bio Pharma Buffer Sales by Type (2018-2023)
4.1.2 Global Bio Pharma Buffer Revenue by Type (2018-2023)
4.1.3 Global Bio Pharma Buffer Price by Type (2018-2023)
4.2 Global Bio Pharma Buffer Market Estimates and Forecasts by Type (2024-2029)
4.2.1 Global Bio Pharma Buffer Sales Forecast by Type (2024-2029)
4.2.2 Global Bio Pharma Buffer Revenue Forecast by Type (2024-2029)
4.2.3 Global Bio Pharma Buffer Price Forecast by Type (2024-2029)
5 Global Bio Pharma Buffer Market Size by Application
5.1 Global Bio Pharma Buffer Historic Market Review by Application (2018-2023)
5.1.1 Global Bio Pharma Buffer Sales by Application (2018-2023)
5.1.2 Global Bio Pharma Buffer Revenue by Application (2018-2023)
5.1.3 Global Bio Pharma Buffer Price by Application (2018-2023)
5.2 Global Bio Pharma Buffer Market Estimates and Forecasts by Application (2024-2029)
5.2.1 Global Bio Pharma Buffer Sales Forecast by Application (2024-2029)
5.2.2 Global Bio Pharma Buffer Revenue Forecast by Application (2024-2029)
5.2.3 Global Bio Pharma Buffer Price Forecast by Application (2024-2029)
6 United States Bio Pharma Buffer Market Facts & Figures
6.1 United States Bio Pharma Buffer Sales by Company
6.1.1 United States Bio Pharma Buffer Sales by Company (2018-2023)
6.1.2 United States Bio Pharma Buffer Revenue by Company (2018-2023)
6.2 United States Bio Pharma Buffer Sales Breakdown by Type
6.2.1 United States Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
6.2.2 United States Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
6.3 United States Bio Pharma Buffer Sales Breakdown by Application
6.3.1 United States Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
6.3.2 United States Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
7 Europe Bio Pharma Buffer Market Facts & Figures
7.1 Europe Bio Pharma Buffer Sales by Company
7.1.1 Europe Bio Pharma Buffer Sales by Company (2018-2023)
7.1.2 Europe Bio Pharma Buffer Revenue by Company (2018-2023)
7.2 Europe Bio Pharma Buffer Sales Breakdown by Type
7.2.1 Europe Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
7.2.2 Europe Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
7.3 Europe Bio Pharma Buffer Sales Breakdown by Application
7.3.1 Europe Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
7.3.2 Europe Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
8 China Bio Pharma Buffer Market Facts & Figures
8.1 China Bio Pharma Buffer Sales by Company
8.1.1 China Bio Pharma Buffer Sales by Company (2018-2023)
8.1.2 China Bio Pharma Buffer Revenue by Company (2018-2023)
8.2 China Bio Pharma Buffer Sales Breakdown by Type
8.2.1 China Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
8.2.2 China Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
8.3 China Bio Pharma Buffer Sales Breakdown by Application
8.3.1 China Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
8.3.2 China Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
9 Japan Bio Pharma Buffer Market Facts & Figures
9.1 Japan Bio Pharma Buffer Sales by Company
9.1.1 Japan Bio Pharma Buffer Sales by Company (2018-2023)
9.1.2 Japan Bio Pharma Buffer Revenue by Company (2018-2023)
9.2 Japan Bio Pharma Buffer Sales Breakdown by Type
9.2.1 Japan Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
9.2.2 Japan Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
9.3 Japan Bio Pharma Buffer Sales Breakdown by Application
9.3.1 Japan Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
9.3.2 Japan Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
10 Southeast Asia Bio Pharma Buffer Market Facts & Figures
10.1 Southeast Asia Bio Pharma Buffer Sales by Company
10.1.1 Southeast Asia Bio Pharma Buffer Sales by Company (2018-2023)
10.1.2 Southeast Asia Bio Pharma Buffer Revenue by Company (2018-2023)
10.2 Southeast Asia Bio Pharma Buffer Sales Breakdown by Type
10.2.1 Southeast Asia Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
10.2.2 Southeast Asia Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
10.3 Southeast Asia Bio Pharma Buffer Sales Breakdown by Application
10.3.1 Southeast Asia Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
10.3.2 Southeast Asia Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
11 India Bio Pharma Buffer Market Facts & Figures
11.1 India Bio Pharma Buffer Sales by Company
11.1.1 India Bio Pharma Buffer Sales by Company (2018-2023)
11.1.2 India Bio Pharma Buffer Revenue by Company (2018-2023)
11.2 India Bio Pharma Buffer Sales Breakdown by Type
11.2.1 India Bio Pharma Buffer Sales Breakdown by Type (2018-2023)
11.2.2 India Bio Pharma Buffer Sales Breakdown by Type (2024-2029)
11.3 India Bio Pharma Buffer Sales Breakdown by Application
11.3.1 India Bio Pharma Buffer Sales Breakdown by Application (2018-2023)
11.3.2 India Bio Pharma Buffer Sales Breakdown by Application (2024-2029)
12 Company Profiles and Key Figures in Bio Pharma Buffer Business
12.1 Avantor
12.1.1 Avantor Corporation Information
12.1.2 Avantor Business Overview
12.1.3 Avantor Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.1.4 Avantor Bio Pharma Buffer Products Offered
12.1.5 Avantor Recent Development
12.2 Alfa Aesar (Thermo Fisher)
12.2.1 Alfa Aesar (Thermo Fisher) Corporation Information
12.2.2 Alfa Aesar (Thermo Fisher) Business Overview
12.2.3 Alfa Aesar (Thermo Fisher) Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.2.4 Alfa Aesar (Thermo Fisher) Bio Pharma Buffer Products Offered
12.2.5 Alfa Aesar (Thermo Fisher) Recent Development
12.3 Merck
12.3.1 Merck Corporation Information
12.3.2 Merck Business Overview
12.3.3 Merck Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.3.4 Merck Bio Pharma Buffer Products Offered
12.3.5 Merck Recent Development
12.4 Lonza
12.4.1 Lonza Corporation Information
12.4.2 Lonza Business Overview
12.4.3 Lonza Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.4.4 Lonza Bio Pharma Buffer Products Offered
12.4.5 Lonza Recent Development
12.5 Bio-Rad
12.5.1 Bio-Rad Corporation Information
12.5.2 Bio-Rad Business Overview
12.5.3 Bio-Rad Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.5.4 Bio-Rad Bio Pharma Buffer Products Offered
12.5.5 Bio-Rad Recent Development
12.6 BD
12.6.1 BD Corporation Information
12.6.2 BD Business Overview
12.6.3 BD Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.6.4 BD Bio Pharma Buffer Products Offered
12.6.5 BD Recent Development
12.7 GE Healthcare
12.7.1 GE Healthcare Corporation Information
12.7.2 GE Healthcare Business Overview
12.7.3 GE Healthcare Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.7.4 GE Healthcare Bio Pharma Buffer Products Offered
12.7.5 GE Healthcare Recent Development
12.8 Promega Corporation
12.8.1 Promega Corporation Corporation Information
12.8.2 Promega Corporation Business Overview
12.8.3 Promega Corporation Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.8.4 Promega Corporation Bio Pharma Buffer Products Offered
12.8.5 Promega Corporation Recent Development
12.9 Hamilton Company
12.9.1 Hamilton Company Corporation Information
12.9.2 Hamilton Company Business Overview
12.9.3 Hamilton Company Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.9.4 Hamilton Company Bio Pharma Buffer Products Offered
12.9.5 Hamilton Company Recent Development
12.10 XZL BIO-TECHNOLOGY
12.10.1 XZL BIO-TECHNOLOGY Corporation Information
12.10.2 XZL BIO-TECHNOLOGY Business Overview
12.10.3 XZL BIO-TECHNOLOGY Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.10.4 XZL BIO-TECHNOLOGY Bio Pharma Buffer Products Offered
12.10.5 XZL BIO-TECHNOLOGY Recent Development
12.11 SRL
12.11.1 SRL Corporation Information
12.11.2 SRL Business Overview
12.11.3 SRL Bio Pharma Buffer Sales, Revenue and Gross Margin (2018-2023)
12.11.4 SRL Bio Pharma Buffer Products Offered
12.11.5 SRL Recent Development
13 Bio Pharma Buffer Manufacturing Cost Analysis
13.1 Bio Pharma Buffer Key Raw Materials Analysis
13.1.1 Key Raw Materials
13.1.2 Key Raw Materials Price Trend
13.1.3 Key Suppliers of Raw Materials
13.2 Proportion of Manufacturing Cost Structure
13.3 Manufacturing Process Analysis of Bio Pharma Buffer
13.4 Bio Pharma Buffer Industrial Chain Analysis
14 Marketing Channel, Distributors and Customers
14.1 Marketing Channel
14.2 Bio Pharma Buffer Distributors List
14.3 Bio Pharma Buffer Customers
15 Market Dynamics
15.1 Bio Pharma Buffer Industry Trends
15.2 Bio Pharma Buffer Market Drivers
15.3 Bio Pharma Buffer Market Challenges
15.4 Bio Pharma Buffer Market Restraints
16 Research Findings and Conclusion
17 Appendix
17.1 Research Methodology
17.1.1 Methodology/Research Approach
17.1.2 Data Source
17.2 Author List
17.3 Disclaimer
Avantor
Alfa Aesar (Thermo Fisher)
Merck
Lonza
Bio-Rad
BD
GE Healthcare
Promega Corporation
Hamilton Company
XZL BIO-TECHNOLOGY
SRL
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*If Applicable.